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仪器网/ 行业应用/ 解决方案/ 静脉输液袋系统的可萃取物和可浸出物分析

静脉输液袋系统的可萃取物和可浸出物分析

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To ensure the safety of pharmaceutical products, the monitoring of potentially harm-ful contaminants originating from the product itself or its packaging is necessary. In this study, IV bag components were analyzed for extractables using direct thermal desorption/thermal extraction combined with unit resolution GC/MS system. The results were compared to those obtained for leachables by stir bar sorptive extrac-tion of an aqueous solution stored in the exact same type of IV bag, again combined with GC/MS determination of the leached compounds. In addition, a high resolution GC/Q-TOF mass spectrometer was used to confirm or refute some of the analyte identifications obtained using commercial library searches with the unit resolution MSD system. Agilent 5977B 单四极杆气质联用系统GC/MSD
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