Anti-connexin 43 抗体说明书

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【导读】Anti-connexin43抗体说明书 Anti-connexin43抗体说明书CatalogNumber:RS-0651R Quantitysize: 0.1...

Anti-connexin43抗体说明书

CatalogNumber:RS-0651R Quantitysize: 0.1ml （dilutewithpH7.4 0.01MPBSorantibodydiluent）Background: Theconnexinfamilyofproteinsformhexamericcomplexescalled“connexons”thatfacilitatemovementoflowmolecularweightproteinsbetweencellsviagapjunctions.Connexinproteinsshareacommontopologyof4transmembranealpha-helicaldomains,twoextracellularloops,acytoplasmicloop,andcytoplasmicN-andC-termini.Manyofthekeyfunctionaldifferencesarisefromspecificamino-acidsubstitutionsinthemosthighlyconserveddomains,thetransmembraneandextracellularregions.Eachoftheapproximately20connexinisoformsproducechannelswithdistinctpermeabilitiesandelectricalandchemicalsensitivities;therefore,oneconnexinusuallycannotfullysubstituteforanother.Consequently,awidevarietyofmalignantphenotypesassociatewithdecreasedconnexinexpressionandgapjunctioncommunication,dependentontheparticularconnexinthatiseffected.Forinstance,connexin43malfunctionmaycausearrythmiaandventriculardysfunction,leadingtoavarietyofacquiredheartdiseases. Anti-connexin43抗体说明书pecificity: – connexin43isaGoatmonoclonalantibodyunconjugated. – specificforconnexin43 ofhuman,mouse,rat,rabbitanddog – useforwesternblotting,elisa,immunoprecipitationandimmunohistochemistry– ProteinGaffinitychromatographypurification,purity:>95%– Isotype: IgG– molwt: 43kDaApplication: – Westernblotting1:100-500 – Immunohistochemistry1:100-500 – ELISA1:500-1000 – Optimalworkingdilutionsmust bedeterminedbytheenduser.Storage: Storeat-20℃foroneyear.Avoidrepeatedfreeze/thawcycles.The lyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreater thanayearwhenkeptat-20℃.WhenreconstitutedinsterilepH7.40.01MPBSordiluent ofantibody,theantibodyisstableforatleastsixweeksat2-4℃ ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforusein human,therapeuticordiagnosticapplications.

Anti-connexin43抗体说明书

2004-07-13 09:31:27

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