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化工专业英语求翻译

w张女士    2013-11-13    嵌段共聚物    浏览 382 次

Hollow polymeric spheres have been attracting increasing interest because of their potential applications, which range from targeted drug delivery to advanced functional materi- als.[1,2] Because of their hollow core structure, such poly... Hollow polymeric spheres have been attracting increasing
interest because of their potential applications, which range
from targeted drug delivery to advanced functional materi-
als.[1,2] Because of their hollow core structure, such polymeric
spheres can encapsulate large quantities of guest moleculesÐ
especially those spheres with functionalities within the empty
coreÐand release them at a later stage in a controlled man-
ner. Although hollow polymeric spheres with dimensions in
the micrometer and submicrometer regions are readily con-
structedÐby layer-by-layer deposition of polyelectrolytes
onto a template core,[3±6] polymerizing monomers in lipid vesi-
cles,[7,8] emulsion polymerization,[9,10] pH-induced micelliza-
tion of a grafted copolymer,[11] and by the assembly of posi-
tively charged polyelectrolytes and negatively charged
nanoparticles[12]Ðthe synthesis of hollow spheres 100 nm or
less in size has only recently become the subject of research
activity. Several different routes, such as the self-assembly of
block copolymers in a selective solvent,[13,14] the deposition of
polyelectrolytes on a decomplexable or soluble core,[15,16] and
microemulsion (as well as miniemulsion) polymerization,[17,18]
have been developed to form hollow polymeric nanospheres.
Although some of these methods have been quite successful,
these strategies require the core templates to be removed in
order to create a hollow interior, or need large quantities of
surfactants to form nanosized micelles. Furthermore, although
the majority of the proposed applications of hollow nano-
spheres or nanocapsules are concentrated in the biomedical
field, most of the hollow polymeric spheres described to date
are ill-suited for such purposes. Therefore, materials (in par-
ticular for the surfaces of the hollow nanospheres) that are
biocompatible, non-toxic, and sometimes also biodegradable,
are highly desirable. Herein, we demonstrate a simple and di-
rect method for fabricating hollow polymeric nanospheres
with biocompatible and biodegradable macromolecules. In
this approach, hollow polymeric nanospheres were formed in
a completely aqueous system without the aid of surfactants,

精彩问答
久伴派大星pM7 发布日期:2013-11-14
因其在从靶向给药到先进的功能材料领域的潜在应用,聚合物空心球受到越来越多的关注。由于它们的中空结构,聚合物球能包覆大量的客体分子,尤其是那些具有内空心功能的聚合物球,能在之后的阶段以受控的方式释放它们。虽然尺寸在微米和亚微米区域的空心聚合物球体很容易被一层层沉积在模板的核心聚合电解质构造而成,但是聚合单体在脂质囊泡,乳液聚合,pH诱导胶束化的接枝共聚物,和由带正电荷的聚电解质的组装和带负电的纳米粒子的空心微球的合成100nm或更小的大小,只是在Z近才成为研究活动的主题。几个不同的路线,比如嵌段共聚物在选择性溶剂的自组装,聚合电解质在不可复合的或可溶的核心的沉积,微乳液(以及实验)聚合,已经发展形成空心聚合物纳米团簇。尽管其中的一些方法已经相当成功,这些策略需要核心模板被删除以创建一个中空的内部,或者需要大量的表面活性剂形成纳米胶束。此外,虽然大多数的提出应用空心簇或所研发的纳米囊都集中在生物医学领域,大多数的空心聚合物领域描述到目前为止已经不适合这种用途。因此,材料(特别是对于表面的空心纳米团簇)是生物相容的,无毒的,有时也可生物降解性,是非常可取的。在这里,我们展示了一个简单直接的方法制造空心聚合物纳米球的生物相容性和生物降解的大分子。在这种方法中,在一个完全的含水系统形成了空心聚合物纳米球而不借助表面活性剂。
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