同位素技术-同位素示踪法的技术原理

全国同位素标记物-北京同位素技术-上海同位素示踪法

随着多肽在生物医药领域越来越广泛和深入的应用，标记和修饰性的多肽种类的需求越来越多，质量需求也越来越高。稳定同位素标记就是其中典型的一种。稳定同位素标记示踪，可以实现肽类代谢途径研究，能够随时追踪含有同位素标记的多肽在体内或体外位置及数量的变化情况。同位素标记具有高灵敏度、定位简单、定量准确等优点，使得同位素修饰在医学及生物化学领域得到越来越广泛的关注。

目前我们公司合成的同位素标记多肽主要为C13，N15两种同位素标记的多肽，通过直接在肽链中引入同位素标记的氨基酸达到有效标记整条肽链的目的，常用的同位素标记的氨基酸有Tyr，Thr,Lys,Arg,Glu等。

同位素标记的多肽与普通肽的区别在于其结构中某一个或几个氨基酸中的C被C13取代或者N被N15取代。

专业的团队，yi流的合成纯化技术，严谨的工作态度，严格的质量要求，是我们能够满足客户对同位素标记多肽的不同纯度要求的重要保障。与此同时，同位素标记多肽的原料（同位素标记的氨基酸）价格昂贵，使得我们合成成本高，这就直接导致了这种多肽价格的高昂，秉着客户至上，竭力满足客户需求的经营理念，我们国肽生物提供微克，毫克到千克级别的质量服务。

成功案例：

序列WVQTLSEQVQEELLSSQVTQEL[13C-15N-R]

HPLC分析：

MS分析：

合肥国肽生物官网：http://www.bankpeptide.com

欢迎咨询服务热线：17718122684；17718122172；17730030476；17718122397

翻译：

translation:

Isotope labe领-isotope technique-isotope tracer

With the increasing and intensive use of peptides in the biomedical field, there is an increasing demand for labeled and modified peptide species, and quality requirements are increasing. Stable isotope labe领 is one of them. Stable isotope labe领 can be used to study peptide metabolic pathways, and to track changes in the location and quantity of isotopically labeled peptides in vivo or in vitro. Isotope labe领 has the advantages of high sensitivity, simple positioning, accurate quantitation, etc., making isotope modification more and more attention in the field of medicine and biochemistry.

At present, the isotope-labeled peptides synthesized by our company are mainly C13, N15 two isotopically labeled polypeptides. By directly introducing isotopically labeled amino acids into the peptide chain, the purpose of effectively labe领 the entire peptide chain is achieved. The commonly used isotopically labeled amino acids are Tyr. Thr, Lys, Arg, Glu, etc.

An isotopically-labeled polypeptide differs from a normal peptide in that C in one or several amino acids in its structure is substituted by C13 or N is substituted by N15.

The professional team, first-class synthetic purification technology, rigorous work attitude and strict quality requirements are important guarantees for our customers to meet the different purity requirements of isotopically labeled peptides. At the same time, the raw material of the isotope-labeled peptide (isotopically labeled amino acid) is expensive, which makes our synthesis cost high, which directly leads to the high price of this peptide, and the business philosophy of customer first and endeavor to meet customer needs. National peptide organisms provide micrograms, milligrams to kilograms of quality service.

success case:

Sequence WVQTLSEQVQEELLSSQVTQEL[13C-15N-R]

HPLC analysis:

MS analysis:

Bankpeptide biological technology co.,LTD: http://www.bankpeptide.com

Welcome to the hotline: 17718122684; 17718122172; 17730030476; 17718122397