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公司新闻
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Anti-Snail 1抗体
发布:上海瑞齐生物科技有限公司浏览次数:436RabbitAnti-Snail1antibody
CatalogNumber:RS-01371R
Quantitysize:0.1ml(dilutewithpH7.40.01MPBSorantibodydiluent)Background:Thezincfingertranscriptionfactor'SNAIL'wasfirstidentifiedinDrosophilaand,alongwith'twist',abasichelix-loop-helixtranscriptionfactor,isindispensableformesodermformation.SNAILisarepressorofmouseE-cadherintranscription,withexpressionofSNAILinverselycorrelatedwithexpressionofE-cadherin.AbnormalexpressionofSNAILcouldunderliethetumorigenicconversionofepitheliaassociatedwithlossofE-cadherinexpressionthroughscreeningmouseandhumancelllinesandbyinsituhybridizationofprimaryhumantumorsundergoingmalignantprogression.
Function:
Involvedintheepithelialtomesenchymaltransition(EMT)andformationandmaintenanceofembryonicmesoderm.Bindsto3E-boxesoftheE-cadheringenepromoterandrepressesitstranscription.
Specificity:Anti-Snail1isarabbitpolyclonalantibody
specificforSnail1ofhuman,rat,mouse
useforwesternblotting,elisa,immunoprecipitationandimmunohistochemistry
ProteinGaffinitychromatographypurification,purity:>95%
Isotype:IgG
molwt:29kDa
Application:
WB=1:100-500ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500
notyettestedinotherapplications.
optimaldilutions/concentrations首ldbedeterminedbytheenduser..Storage:Storeat-20℃foroneyear.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20℃.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibody,theantibodyisstableforatleastsixweeksat2-4℃
ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications.
2016-02-16 -
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