i- RELN/Reelin抗体，说明书现货

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【导读】i-RELN/Reelin抗体，说明书现货 Anti- RELN/Reelin抗体，说明书现货From:ABCAM ...

i-RELN/Reelin抗体，说明书现货

Anti- RELN/Reelin抗体，说明书现货

From:ABCAM

Catalog Number :RS- 1560R

Quantity size : 0.1ml (dilute with pH 7.4 0.01 M PBS or antibody diluent ) Background: Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in “reeler” mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1 in a signa领 pathway that controls cell positioning in the developing brain and is also thought to be a direct effector of the neurotrophin BDNF.
Function : This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.
Subcellular Location : Secreted

.Specificity : Anti –Reelin is amouse monoclonal antibody

specific for Reelin of Human,

use for western blotting,elisa,immunoprecipitation and immunohistochemistry

Protein G affinity chromatography purification, purity :>95%Isotype: IgGmol wt: 400-450;300;180-i-RELN/Reelin抗体，说明书现货200kDa

Application :

WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500KLH conjugated synthetic peptide derived from human RELN C-terminusnot yet tested in other applications.
optimal dilutions/concentrations 首ld be determined by the end user..

Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃

i-RELN/Reelin抗体，说明书现货

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

2004-07-13 09:31:27

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