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上海长方光学仪器有限公司

Anti-DCP荧光抗体说明书

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【导读】 RabbitantibodyCatalogNumber:RS-1037RQuantity size:  0.1ml (dilutewithpH7.4   0.01MPBS...

Rabbitantibody

CatalogNumber:RS-1037R

Quantity size:  0.1ml (dilutewithpH7.4   0.01MPBSorantibodydiluent)

background:

Des-gammacarboxyprothrombin(DCP),alsoknownasproteininducedbyvitaminKabsence/antagonist-II(PIVKA-II),isanabnormalformofthecoagulationprotein,prothrombin.Normally,theprothrombinprecursorundergoespost-translationalcarboxylation(additionofacarboxylicacidgroup)bygamma-glutamylcarboxylaseintheliverpriortosecretionintoplasma.DCP/PIVKA-IImaybedetectedinpeoplewithdeficiencyofvitaminK(duetopoornutritionormalabsorption)andinthosetakingwarfarinorothermedicationthatinhibitstheactionofvitaminK.

 

Function:

Thrombin,whichcleavesbondsafterArgandLys,convertsfibrinogentofibrinandactivatesfactorsV,VII,VIII,XIII,and,incomplexwiththrombomodulin,proteinC.Functionsinbloodhomeostasis,inflammationandwoundhea领.

Subunit:

Heterodimer(namedalpha-thrombin)ofalightandaheavychain;disulfide-linked.FormsaheterodimerwithSERPINA5.

Specificity: Anti-DCP isarabbitpolyclonal antibody              

specificfor DCP of  Human, Mouse, Rat, 

useforwesternblotting,elisa,immunoprecipitationandimmunohistochemistry

ProteinGaffinitychromatographypurification,purity:>95%Isotype: IgG  molwt:  70kDa

Application:  

 WB=1:100-500ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500KLHconjugatedsyntheticpeptidederivedfromhumanDCPnotyettestedinotherapplications.optimaldilutions/concentrations首ldbedeterminedbytheenduser..

Storage: Storeat-20℃ foroneyear.Avoidrepeatedfreeze/thawcycles.The lyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreater thanayearwhenkeptat-20℃.WhenreconstitutedinsterilepH7.40.01MPBSordiluent ofantibody,theantibodyisstableforatleastsixweeksat2-4℃

 

ImportantNote: Thisproductassuppliedisintendedforresearchuseonly,notforusein human,therapeuticordiagnosticapplications.

  

2004-07-13 09:31:27
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